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Showing results for JAG1 and neural
Search for JAG1 and NEURL instead (1 results)
Hoxb3 Regulates Jag1 Expression in Pharyngeal Epithelium and Affects Interaction With Neural Crest Cells.
Zhang H, Xie J, So KKH, Tong KK, Sae-Pang JJ, Wang L, Tsang SL, Chan WY, Wong EYM, Sham MH. Zhang H, et al. Front Physiol. 2021 Jan 11;11:612230. doi: 10.3389/fphys.2020.612230. eCollection 2020. Front Physiol. 2021. PMID: 33505317 Free PMC article.
By molecular experiments, we demonstrated that Hoxb3 could bind to an upstream genomic site S2 and directly regulate Jag1 expression. In the Hoxb3 (Tg/+) mutant, elevated expression of Jag1 in the pharyngeal epithelium led to abnormal cellular interaction and defici …
By molecular experiments, we demonstrated that Hoxb3 could bind to an upstream genomic site S2 and directly regulate Jag1 expression. …
Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor Cells.
Li XJ, Liu XJ, Yang B, Fu YR, Zhao F, Shen ZZ, Miao LF, Rayner S, Chavanas S, Zhu H, Britt WJ, Tang Q, McVoy MA, Luo MH. Li XJ, et al. J Virol. 2015 Jul;89(13):6792-804. doi: 10.1128/JVI.00351-15. Epub 2015 Apr 22. J Virol. 2015. PMID: 25903338 Free PMC article.
Human cytomegalovirus (HCMV) infection of the developing fetus frequently results in major neural developmental damage. In previous studies, HCMV was shown to downregulate neural progenitor/stem cell (NPC) markers and induce abnormal differentiation. ...Transient ex …
Human cytomegalovirus (HCMV) infection of the developing fetus frequently results in major neural developmental damage. In previous s …
Tbx1 and Jag1 act in concert to modulate the fate of neurosensory cells of the mouse otic vesicle.
Macchiarulo S, Morrow BE. Macchiarulo S, et al. Biol Open. 2017 Oct 15;6(10):1472-1482. doi: 10.1242/bio.027359. Biol Open. 2017. PMID: 28838968 Free PMC article.
The Tbx1 transcription factor gene expression pattern is complementary to the NSD, and inactivation results in expansion of the NSD and expression of the Notch ligand, Jag1 mapping, in part of the NSD. To shed light on the role of Jag1 in NSD development, as well as …
The Tbx1 transcription factor gene expression pattern is complementary to the NSD, and inactivation results in expansion of the NSD and expr …
JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling.
Kamalakar A, McKinney JM, Salinas Duron D, Amanso AM, Ballestas SA, Drissi H, Willett NJ, Bhattaram P, García AJ, Wood LB, Goudy SL. Kamalakar A, et al. Bone. 2021 Feb;143:115657. doi: 10.1016/j.bone.2020.115657. Epub 2020 Sep 25. Bone. 2021. PMID: 32980561 Free PMC article.
Development of a bone-regenerative therapy for children will transform our ability to reduce the morbidity associated with current autologous bone grafting techniques. We discovered that JAGGED1 (JAG1) induces cranial neural crest (CNC) cell osteoblast commitment du …
Development of a bone-regenerative therapy for children will transform our ability to reduce the morbidity associated with current autologou …
Biomedical engineering approaches for the delivery of JAGGED1 as a potential tissue regenerative therapy.
Kaimari S, Kamalakar A, Goudy SL. Kaimari S, et al. Front Bioeng Biotechnol. 2023 Sep 11;11:1217211. doi: 10.3389/fbioe.2023.1217211. eCollection 2023. Front Bioeng Biotechnol. 2023. PMID: 37781534 Free PMC article. Review.
For JAG1-NOTCH signaling to occur, JAG1 must be immobilized within a scaffold and the correct orientation between the NOTCH receptor and JAG1 must be achieved. ...This review discusses the role of JAG1 in disease, the clinical role of JAG1 as a …
For JAG1-NOTCH signaling to occur, JAG1 must be immobilized within a scaffold and the correct orientation between the NOTCH re …
Human cytomegalovirus infection perturbs neural progenitor cell fate via the expression of viral microRNAs.
Jiang X, Liu S, Fu YR, Liu XJ, Li XJ, Yang B, Jiang HF, Shen ZZ, Alemu EA, Vazquez P, Tang Y, Kaarbø M, McVoy MA, Rayner S, Luo MH. Jiang X, et al. J Med Virol. 2023 Feb;95(2):e28574. doi: 10.1002/jmv.28574. J Med Virol. 2023. PMID: 36772841
Human cytomegalovirus (HCMV) preferentially targets neural progenitor cells (NPCs) in congenitally infected fetal brains, inducing neurodevelopmental disorders. ...Reduction of Jag1 RNA and protein levels in NPCs was observed in response to transient expression of h …
Human cytomegalovirus (HCMV) preferentially targets neural progenitor cells (NPCs) in congenitally infected fetal brains, inducing ne …
PRDM16 expression and function in mammalian cochlear development.
Ebeid M, Barnas K, Zhang H, Yaghmour A, Noreikaite G, Bjork BC. Ebeid M, et al. Dev Dyn. 2022 Oct;251(10):1666-1683. doi: 10.1002/dvdy.480. Epub 2022 May 7. Dev Dyn. 2022. PMID: 35451126 Free PMC article.
BACKGROUND: PR domain containing 16 (PRDM16) is a key transcriptional regulator in the development of craniofacial, adipose, and neural tissues. Our lab identified PRDM16 expression in the epithelial cells of the Kolliker's organ (KO) that starts at ~E13.5 and is maintaine …
BACKGROUND: PR domain containing 16 (PRDM16) is a key transcriptional regulator in the development of craniofacial, adipose, and neural …
Two Notch ligands, Dll1 and Jag1, are differently restricted in their range of action to control neurogenesis in the mammalian spinal cord.
Ramos C, Rocha S, Gaspar C, Henrique D. Ramos C, et al. PLoS One. 2010 Nov 24;5(11):e15515. doi: 10.1371/journal.pone.0015515. PLoS One. 2010. PMID: 21124801 Free PMC article.
This mild Jag1 phenotype contrasts with the strong neurogenic phenotype detected in Dll1 mutants and led us to hypothesize that neighbouring Dll1-expressing cells signal to V1 and dI6 progenitors and restore neurogenesis in the absence of Jag1. ...However, Jag1 …
This mild Jag1 phenotype contrasts with the strong neurogenic phenotype detected in Dll1 mutants and led us to hypothesize that neigh …
Metal transporter Slc30a1 controls pharyngeal neural crest differentiation via the zinc-Snai2-Jag1 cascade.
Xia Z, Bi X, Yang S, Yang X, Song Z, Wei J, Xu P, Rink L, Min J, Wang F. Xia Z, et al. MedComm (2020). 2021 Sep 27;2(4):778-797. doi: 10.1002/mco2.91. eCollection 2021 Dec. MedComm (2020). 2021. PMID: 34977877 Free PMC article.
The pharyngeal arch (PA) is a neural crest (NC)-derived organ that is transiently developed during embryogenesis and is required for the subsequent development of various tissues. ...
The pharyngeal arch (PA) is a neural crest (NC)-derived organ that is transiently developed during embryogenesis and is required for …
Novel JAG1 Deletion Variant in Patient with Atypical Alagille Syndrome.
Micaglio E, Andronache AA, Carrera P, Monasky MM, Locati ET, Pirola B, Presi S, Carminati M, Ferrari M, Giamberti A, Pappone C. Micaglio E, et al. Int J Mol Sci. 2019 Dec 11;20(24):6247. doi: 10.3390/ijms20246247. Int J Mol Sci. 2019. PMID: 31835735 Free PMC article.
Genetic testing revealed the novel variant c.802del in a single copy of the JAG1 gene. No variants in the NOTCH2 gene were detected. To the best of our knowledge, this is the first clinical description of a congenital neural tube defect in a molecularly confirmed Al …
Genetic testing revealed the novel variant c.802del in a single copy of the JAG1 gene. No variants in the NOTCH2 gene were detected. …
85 results